Epimune Complex

Key Ingredients in Epimune Complex

Organic Acerola

• Known as an antioxidant superfruit, Acerola (Malpighia emarginata DC.) is one of the richest plant-based sources of phytonutrients including antioxidant vitamin C^1,2 — a key player in a healthy immune system and immune response to seasonal challenges.^3,4
• Supports mucosa, cell function, skin, blood vessels, and other tissue via its role in collagen synthesis and antioxidant activity

Calcium lactate

• Highly bioavailable calcium that supports numerous actions in the body (involved in cell signaling)
• Source of dietary calcium: a mineral that supports a healthy immune response including cell signaling in lymphocytes — a type of white blood cell.^5,6

Zinc rice chelate

• Plays a structural role in proteins and helps protect cell membranes while influencing cell communication, hormone release, and cell death
• Source of dietary zinc: an antioxidant mineral that plays a key role in a healthy immune response⁴ and cell membrane support.^4,7,8

Turkey Tail and Maitake Mushrooms

• Whole food powders of the mycelium of Grifola frondosa (Maitake) and Coriolus versicolor (Turkey-tail) mushrooms
• A growing body of research suggests that both Maitake and Turkey Tail mushrooms and extracts provide a variety of health-promoting properties including a healthy immune system support.^9-15

Research-supported Ingredients in Epimune Complex

EpiCor® 

EpiCor® is a whole food fermentate comprised of proteins, fibers, polyphenols, vitamins, amino acids and beta glucans that have been clinically shown to provide significant immune health benefits.^16-21 In a randomized, double-blind, placebo-controlled clinical trial consisting of individuals with no recent history of seasonal influenza vaccination, participants received 500 mg of EpiCor® once per day or placebo for 12 weeks. Those participants receiving EpiCor® experienced a significant reduction in their incidence of cold or flu-like symptoms (p=0.01) compared to the placebo group.²²

MaitakeGold 404® extract 

MaitakeGold 404® (15%) is a proprietary combination of a certified organic maitake mushroom powder from mycelial biomass (85% by weight) and maitake mushroom fruit body extract (15% by weight) derived under a patented method from the fruit body of Maitake. In an animal study, MaitakeGold 404® has been reported to stimulate phagocytosis (part of the innate immune response) and increase the numbers of some specific immune cells (i.e. phagocytosis monocytes and macrophages).²² In another animal study, short-term oral administration of MaitakeGold 404® strongly stimulated a healthy immune reaction.²³ These results indicate a broad-based immune system support that is part of the body’s first line of immune activity.*

References:

1. Prakash, A. & Baskaran, R. J Food Sci Technol 55, 3373-3384, doi:10.1007/s13197-018-3309-5 (2018).

2. Cefali, L. C. et al. J AOAC Int 101, 1461-1465, doi:10.5740 jaoacint.18-0008 (2018).

3. Maggini, S., Pierre, A. & Calder, P. C. Nutrients 10, doi:10.3390/nu10101531 (2018).

4. Gombart, A. F., Pierre, A. & Maggini, S. Nutrients 12, doi:10.3390/nu12010236 (2020).

5. Vig, M. & Kinet, J. P. Nat Immunol 10, 21-27, doi:10.1038/ni.f.220 (2009).

6. Feske, S. Nat Rev Immunol 7, 690-702, doi:10.1038/nri2152 (2007).

7. Prasad, A. S. Mol Med 14, 353-357, doi:10.2119/2008-00033.Prasad (2008).

8. Prasad, A. S. Exp Gerontol 43, 370-377, doi:10.1016/j.exger.2007.10.013 (2008).

9. Zhang, Y. et al. Int J Mol Med 40, 1089-1095, doi:10.3892/ijmm.2017.3081 (2017).

10. Chen, P., Liu, H. P., Ji, H. H., Sun, N. X. & Feng, Y. Y. Int J Biol Macromol 125, 1232-1241, doi:10.1016/j.ijbiomac.2018.09.098 (2019).

11. Benson, K. F. et al. BMC Complement Altern Med 19, 342, doi:10.1186/s12906-019-2681-7 (2019).

12. Jeong, S. C. et al. J Med Food 9, 175-181, doi:10.1089/jmf.2006.9.175 (2006).

13. Roca-Lema, D. et al. Int J Med Sci 16, 231-240, doi:10.7150/ijms.28811 (2019).

14. Deng, G. et al. J Cancer Res Clin Oncol 135, 1215-1221, doi:10.1007/s00432-009-0562-z (2009).

15. Leliebre-Lara, V. et al. Molecules 21, doi:10.3390/molecules21081045 (2016)16. Jensen, G. S.; Patterson, K. M.; Barnes, J.; Schauss, A. G.; Beaman, R.; Reeves, S.; Robinson, L. The Open Nutrition Journal 2008, 2,

68-75.

17. Moyad, M. A.; Robinson, L. E.; Zawada, E. T., Jr.; Kittelsrud, J. M.; Chen, D. G.; Reeves, S. G.; Weaver, S. E. Urol Nurs 2008, 28 (1), 50-5.

18. Moyad, M. A.; Robinson, L. E.; Zawada, E. T.; Kittelsrud, J.; Chen, D. G.; Reeves, S. G.; Weaver, S. J Altern Complement Med 2010, 16

(2), 213-8.

19. Moyad, M. A.; Robinson, L. E.; Kittelsrud, J. M.; Reeves, S. G.; Weaver, S. E.; Guzman, A. I.; Bubak, M. E. Adv Ther 2009, 26 (8), 795-804.

20. Jensen, G. S.; Redman, K. A.; Benson, K. F.; Carter, S. G.; Mitzner, M. A.; Reeves, S.; Robinson, L. J Med Food 2011, 14 (9), 1002-10.trial.

21. Jensen, G. S., Carter, S. G., Reeves, S. G., Robinson, L. E., & Benson, K. F. (2015). J Med Food, 18(3), 378–384.

22. Vetvicka, V., et al. JANA 2005, 8(3):33-39.

23. Vetvicka, V. & Vetvickova, J. Ann Transl Med 2, 14, doi:10.3978/j.issn.2305-5839.2014.01.05 (2014).